PT-141

PT‑141 Peptide — Research Overview. PT‑141 (Bremelanotide) is a synthetic peptide derived from the α‑MSH hormone family. It is widely studied for its effects on melanocortin receptors, particularly those involved in sexual function, arousal pathways, and central nervous system signaling. Unlike other melanocortin peptides, PT‑141 is designed to act on the brain rather than influence skin pigmentation.

Key Research Findings

1. Sexual Function Research

• Studied for its ability to support erectile function
• May help improve sexual desire and arousal pathways
• Research includes both male and female models

2. Libido & Arousal Signaling

• Influences melanocortin pathways linked to motivation and desire
• May increase activity in brain regions associated with sexual interest

3. Central Nervous System Activity

• Acts directly on hypothalamic receptors
• May influence dopamine‑related signaling involved in arousal

4. Rapid Onset

• Research notes relatively fast activation of melanocortin pathways

Molecular make up:

• Synonym: Bremelanotide
• Peptide Class: Cyclic heptapeptide
• IUPAC Name: Ac‑Nle‑cyclo(Asp‑His‑D‑Phe‑Arg‑Trp‑Lys)‑OH
• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: ~1025.2 g/mol
• CAS Number: 189691‑06‑3